发明申请
US20050215541A1 CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
失效
环己基，LACTAM，LACTONE和相关化合物，包含其的药物组合物，以及抑制β-淀粉样肽释放和/或通过使用这些化合物合成的方法
- 专利标题： CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
- 专利标题（中）： 环己基，LACTAM，LACTONE和相关化合物，包含其的药物组合物，以及抑制β-淀粉样肽释放和/或通过使用这些化合物合成的方法
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申请号： US10951992申请日： 2004-09-29
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公开(公告)号： US20050215541A1公开(公告)日： 2005-09-29
- 发明人: Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
- 申请人： Jing Wu , Jay Tung , Eugene Thorsett , Michael Pleiss , Jeffrey Nissen , R. Jeffrey Neitz , Lee Latimer , Varghese John , Stephen Freedman , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , James Droste , Steven Henry , Stacey McDaniel , William Scott , Russell Stucky , Warren Porter
- 专利权人： Athena Neurosciences, Inc. and Eli Lilly & Company
- 当前专利权人： Athena Neurosciences, Inc. and Eli Lilly & Company
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4015 ; A61K31/445 ; A61K31/55 ; A61K38/04 ; A61K38/05 ; A61P25/28 ; C07D223/18 ; C07D471/04 ; C07D471/06 ; C07D471/08
摘要：
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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