- 专利标题: Cyclic peptide antifungal agents and process for preparation thereof
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申请号: US11078791申请日: 2005-03-10
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公开(公告)号: US20050181984A1公开(公告)日: 2005-08-18
- 发明人: Frederick Burkhardt , Manuel Debono , Jeffrey Nissen , William Turner
- 申请人: Frederick Burkhardt , Manuel Debono , Jeffrey Nissen , William Turner
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K7/56 ; A61K38/12 ; C07K5/12
摘要:
Provided are compounds of the formula (1): wherein R′ is hydrogen, methyl or NH2C(O)CH2—; R″ and R′″ are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R═H) forms of the compounds.
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