The invention relates to a liquid spray bottle with combined drive, equipped with a liquid propulsion member (50) that has a main axis of translation (XnullX) coupled, on the one hand, to a spray member (9) comprising a nozzle (11) having an axis of diffusion (YnullY) and, on the other hand, to a container (3) containing the liquid. The spray bottle comprises a rigid casing (1a, 1b; 20a, 20b) which partially surrounds the container (3) and which extends roughly in a main plane (P) containing the axis of translation (XnullX), a connecting member (13) connecting the spray head (9) and the casing, and a region (7, 10d) of sliding between the container and the casing, so that manual thrust ({right arrow over (F)}1) exerted laterally on the container in the main plane (P) of the casing causes, through a combination of the action of the sliding ramp (10d) and of the connecting member (13), actuation of the propulsion member (50) to spray the liquid and a movement of the bottle, with respect to the casing, in a pendular movement about an axis of pivoting located near the propulsion member (50) and which, by converting the movement, generates translation along said axis of translation (XnullX) to actuate the spraying of the liquid through the nozzle (11).