Invention Application
US20040022794A1 Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease
审中-公开
核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗
- Patent Title: Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of Alzheimer's disease
- Patent Title (中): 核酸分子，多肽及其用途，包括阿尔茨海默病的诊断和治疗
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Application No.: US10264309Application Date: 2002-10-03
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Publication No.: US20040022794A1Publication Date: 2004-02-05
- Inventor: L. Kathryn Durham , David L. Friedman , Herath Mudiyanselage Athula Chandrasiri Herath , Lida H. Kimmel , Rajesh Bhikhu Parekh , David M. Potter , Christian Rohlff , B. Michael Silber , Peter Jeffrey Snyder , Holly Daria Soares , Thomas R. Stiger , P. Trey Sunderland , Robert Reid Townsend , W. Frost White , Stephen A. Williams
- Main IPC: A61K048/00
- IPC: A61K048/00 ; C12Q001/68 ; G01N033/53 ; G01N033/542 ; A61K039/00 ; C07K016/40
Abstract:
The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
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