发明申请
- 专利标题： 1,3-Diheterocyclic metalloprotease inhibitors
- 专利标题（中）： 1,3-二杂环金属蛋白酶抑制剂
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申请号： US10228490申请日： 2002-08-27
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公开(公告)号： US20030130271A1公开(公告)日： 2003-07-10
- 发明人: Stanislaw Pikul , Kelly Lynn McDow-Dunham , Neil Gregory Almstead , Biswanath De , Michael George Natchus , Yetunde Olabisi Taiwo
- 申请人： The Procter & Gamble Company
- 申请人地址： null
- 专利权人： The Procter & Gamble Company
- 当前专利权人： The Procter & Gamble Company
- 当前专利权人地址： null
- 主分类号： C07D279/04
- IPC分类号： C07D279/04 ; C07D265/04 ; A61K031/54 ; A61K031/535
摘要：
The invention provides compounds of formula 1 as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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