A multi-piece golf ball includes a core having a diameter of 30 to 40 mm, at least one intermediate layer including the outermost layer having a thickness of 0.5 to 2.0 mm, and a cover having a thickness of 0.5 to 2.0 mm. The core is made from a rubber composition mainly containing polybutadiene. The outermost layer is made from a resin material containing an ionomer resin in an amount of 30% by weight or more. The cover is made from a material obtained by dispersedly blending at least one kind of silicone powder selected from a silicone rubber powder, a silicon resin powder, and a composite powder thereof, in a main resin component containing an ionomer resin in an amount of 50% by weight or more. The hardness of said cover is smaller than the hardness of said outermost layer of said at least one intermediate layer and is larger than the hardness of a center portion of said core. The multi-piece golf ball is excellent in resilience, durability, feel of hitting, and controllability.