Invention Grant
- Patent Title: De novo design of potent and selective interleukin mimetics
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Application No.: US18187639Application Date: 2023-03-21
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Publication No.: US12227553B2Publication Date: 2025-02-18
- Inventor: Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey
- Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Applicant Address: US WA Seattle; US CA Stanford
- Assignee: UNIVERSITY OF WASHINGTON,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee: UNIVERSITY OF WASHINGTON,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee Address: US WA Seattle; US CA Stanford
- Agency: MCDONNELL BOEHNEN HULBERT AND BERGHOFF LLP
- Main IPC: C07K14/55
- IPC: C07K14/55 ; A61K38/00 ; A61K47/60 ; A61K47/62 ; C07K14/54
Abstract:
De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
Public/Granted literature
- US20240076342A1 De Novo Design of Potent and Selective Interleukin Mimetics Public/Granted day:2024-03-07
Information query
