Invention Grant
- Patent Title: Enzymatic mutant suitable for homogeneous immunoassay method
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Application No.: US17428477Application Date: 2020-01-23
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Publication No.: US12188063B2Publication Date: 2025-01-07
- Inventor: Hiroshi Ueda , Jiulong Su , Tetsuya Kitaguchi , Yuki Ohmuro
- Applicant: INSTITUTE OF SCIENCE TOKYO
- Applicant Address: JP Tokyo
- Assignee: INSTITUTE OF SCIENCE TOKYO
- Current Assignee: INSTITUTE OF SCIENCE TOKYO
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2019-021450 20190208
- International Application: PCT/JP2020/002264 WO 20200123
- International Announcement: WO2020/162203 WO 20200813
- Main IPC: C12N9/24
- IPC: C12N9/24 ; C07K19/00 ; C12N15/62 ; C12Q1/34
Abstract:
Provided as a mutant of β glucuronidase suitable for homogeneous immunoassays is a β glucuronidase mutant, wherein, in the amino acid sequence of Escherichia coli β glucuronidase, methionine at position 516 is substituted with lysine, and tyrosine at position 517 is unsubstituted or substituted with a non-tyrosine aromatic amino acid.
Public/Granted literature
- US20220119789A1 ENZYMATIC MUTANT SUITABLE FOR HOMOGENEOUS IMMUNOASSAY METHOD Public/Granted day:2022-04-21
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