Invention Grant
- Patent Title: Receptors providing targeted costimulation for adoptive cell therapy
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Application No.: US17823223Application Date: 2022-08-30
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Publication No.: US12187778B2Publication Date: 2025-01-07
- Inventor: John Bridgeman , Robert Hawkins , Ruben Rodriguez , Gray Kueberuwa
- Applicant: INSTIL BIO (UK) LIMITED
- Applicant Address: GB Manchester
- Assignee: INSTIL BIO (UK) LIMITED
- Current Assignee: INSTIL BIO (UK) LIMITED
- Current Assignee Address: GB Manchester
- Agency: KNOBBE MARTENS OLSON & BEAR LLP
- Main IPC: C07K14/725
- IPC: C07K14/725 ; A61K39/00 ; C07K14/705 ; C12N5/0783 ; C12N15/62 ; C12N15/86
Abstract:
The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.
Public/Granted literature
- US20230002470A1 RECEPTORS PROVIDING TARGETED COSTIMULATION FOR ADOPTIVE CELL THERAPY Public/Granted day:2023-01-05
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