Aspects of the disclosure relate to enhanced network security based on inter-application data flows. A computing platform may monitor, via application programming interfaces, data transmissions between applications. Subsequently, the computing platform may retrieve one or more of a time of the data transmission, a source of the data transmission, and a destination of the data transmission. Then, the computing platform may generate a structured database where a pair of components of the database are dynamically linked to one another when the pair of components corresponds to a source and a destination for a data transmission. Subsequently, the computing platform may train a machine learning model to detect structural patterns within the structured database. Then, the computing platform may generate clusters indicative of similar application profiles. Then, the computing platform may predict an impact of a change in an application profile of an application of the plurality of applications.