An integrated cartridge assembly that is employed with an automated medication administration system in response to the acute medical condition. The cartridge assembly configured to be operatively coupled between a pump assembly and a medical port. The cartridge assembly includes a first cartridge and a second cartridge positioned within a housing. The first cartridge contains a portion of saline, while the second cartridge contains a portion of a medicament. The cartridge assembly also includes a gate member that maintains a separation distance between a manifold assembly and the first and second cartridges when in a locked position when the cartridge assembly is in the stored state. The cartridge assembly is operatively coupled to the medical port via a tube set that is fixedly coupled to the manifold assembly.