A clamping device and method for human-medicine or veterinary-medicine applications for the frictionally engaged locking of at least two holding segments, the clamping device has a first holding segment, a second holding segment; a driveable spindle, via which a rotational movement can be converted into an axial longitudinal movement for spindle-locking the second holding segment, and a threaded plate. In this case, the threaded plate can be moved axially in the opposite direction during the spindle movement, wherein, by counter-movement of the threaded plate, at least one wedge body is moveable in a ramp system, in order to clamp the first holding segment.