Multiplexed fiber optic sensors are able to monitor a multitude of sensor positions along an optical fiber from a single interrogation point. A long-standing goal is to increase the length of fiber and the number of multiplexed sensors without significantly compromising performance or increasing the size, weight, power and cost of the fiber and interrogation system. A technique is provided for performing extremely long-range, multiplexed fiber optic strain sensing in an efficient manner. This technique utilizes a serial optical frequency comb based interrogation system to probe an array of sensors placed along a single optical fiber.