- 专利标题: Biocompatible hydrogel, process for producing same, and use thereof in a mechanical viscosupplementation system
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申请号: US17298349申请日: 2019-12-02
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公开(公告)号: US12102735B2公开(公告)日: 2024-10-01
- 发明人: Jean-Claude Giannotta , Charles Calleja
- 申请人: NVD
- 申请人地址: FR Biot
- 专利权人: NVD
- 当前专利权人: NVD
- 当前专利权人地址: FR Biot
- 代理机构: Seckel IP, PLLC
- 优先权: FR 72196 2018.11.30
- 国际申请: PCT/EP2019/083356 2019.12.02
- 国际公布: WO2020/109628A 2020.06.04
- 进入国家日期: 2021-05-28
- 主分类号: A61L27/16
- IPC分类号: A61L27/16 ; A61L27/18 ; A61L27/20 ; A61L27/52 ; A61L27/54 ; A61L27/58 ; C08L33/26
摘要:
A biocompatible hydrogel has between 0.3% and 30% by weight of dry matter of a copolymer formed at least from acrylamide, chitosan and N,N′-methylenebisacrylamide, as well as a diffusing agent. The diffusing agent is advantageously selected from the group consisting of inert ingredients which have biomechanical properties and active ingredients. A method of manufacturing the hydrogel by copolymerizing, washing, and adding the diffusing agent is provided, as well as a mechanical visco-supplementation system adapted for external or internal use that includes the hydrogel, and an external or internal mechanical visco-supplementation kit including an acrylamide and chitosan copolymer crosslinked with N,N′-methylenebisacrylamide, and a diffusing agent in solid phase or in suspension, the copolymer and the diffusing agent having been previously mixed in the form of a hydrogel during manufacture or being adapted to be mixed extemporaneously to form a hydrogel.
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