The vacuum-based methods of forming an optical fiber preform include applying a vacuum to a preform assembly. The preform assembly has at least one glass cladding section with one or more axial through holes, with one or more canes respectively residing in the one or more axial through holes. The opposite ends of the at least one glass cladding section are capped to define a substantially sealed internal chamber. A vacuum is applied to the substantially sealed internal chamber to define a vacuum-held preform assembly. The methods also include heating the vacuum-held preform assembly to just above the glass softening point to consolidate the vacuum-held preform to form the cane-based glass preform. An optical fiber is formed by drawing the cane-based glass preform. The same furnace used to consolidate the vacuum-held preform can be used to draw the optical fiber.