- 专利标题： Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
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申请号： US17902618申请日： 2022-09-02
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公开(公告)号： US12084452B2公开(公告)日： 2024-09-10
- 发明人: Jacques Banville , Roger Rémillard , Edward H. Ruediger , Daniel H. Deon , Marc Gagnon , Laurence Dubé , Julia Guy , Eldon Scott Priestley , Shoshana L. Posy , Brad D. Maxwell , Pancras C. Wong , R. Michael Lawrence , Michael M. Miller
- 申请人： BRISTOL-MYERS SQUIBB COMPANY , UNIVERSITÉ DE MONTRÉAL
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY,Université de Montréal
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY,Université de Montréal
- 当前专利权人地址： US NJ Princeton; CA Montréal
- 代理机构： Hoffmann & Baron, LLP
- 分案原申请号： US14396771
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/433 ; A61K31/435 ; A61K31/4439 ; A61K31/454 ; A61K31/496 ; A61K31/497 ; A61K31/5025 ; A61K31/5377 ; A61K31/5386 ; A61K31/541 ; A61K31/55 ; A61K31/553 ; A61K45/06 ; A61K51/04 ; C07B59/00 ; C07D513/04 ; C07D519/00
摘要：
The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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