- 专利标题： Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors
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申请号： US17201268申请日： 2021-03-15
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公开(公告)号： US12083101B2公开(公告)日： 2024-09-10
- 发明人: Vincent Bordas , Cara Brocklehurst , Patrick Chene , Pascal Furet , Vito Guagnano , Patricia Imbach-Weese , Joerg Kallen , Mickael Le Douget , Edwige Liliane Jeanne Lorthiois , Joseph McKenna , Bahaa Salem , Tobias Schmelzle , Holger Sellner , Nicolas Soldermann , Markus Voegtle , Markus Wartmann
- 申请人： Novartis AG
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Jessica Chao
- 优先权： EP 163465 2020.03.16
- 主分类号： A61K31/4155
- IPC分类号： A61K31/4155 ; A61K31/343 ; A61K31/351 ; A61K31/357 ; A61K31/4025 ; A61K31/403 ; A61K31/404 ; A61K31/41 ; A61K31/426 ; A61K31/443 ; A61K31/4439 ; A61K31/4525 ; A61K31/506 ; A61P35/00 ; C07D307/81 ; C07D401/14 ; C07D403/04 ; C07D405/04 ; C07D405/10 ; C07D405/12 ; C07D405/14 ; C07D407/04 ; C07D407/12 ; C07D413/04 ; C07D417/04 ; C07D491/04
摘要：
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;
a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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