Disclosed systems and methods include a CPU coupled to one or more storage resources including a hybrid storage resource that is user-configurable during boot to allocate some, all, or none of its capacity as a conventional dual in-line memory module (DIMM) and some, all, or none of its capacity as a persistent storage resource. A utilization efficiency index (UEI) of the hybrid storage resource is assessed. The UEI may be determined based on a combination of memory resource utilization, a persistent storage resource utilization, and weighting parameters that reflect a comparative utility or value of memory vs storage resources. A target division between memory and storage resources may then be determined based on the UEI assessment. The hybrid storage resource may then be configured by dividing or allocating a first portion of its capacity to the volatile memory resource and a remaining portion of its capacity to the persistent storage resource.