The present disclosure relates to a nanobubble generation system using friction in which a frictional force is applied to bubbles included in a gas-liquid mixed fluid so that the atomization of the bubbles is induced and nanobubbles are generated. The nanobubble generation system includes: a chamber including an inlet, an outlet, and an internal space S configured to atomize bubbles included in a gas-liquid mixed fluid; one or more strikers each including a plurality of protrusions provided on a body thereof to simultaneously apply impact to the gas-liquid mixed fluid that flows into the chamber and swirl the fluid in order to cause the gas-liquid mixed fluid to rub against an inner wall of the chamber, the strikers being provided on the driving shaft; a plurality of friction elements provided on the driving shaft in order to apply frictional force to the gas-liquid mixed fluid; and a driving mechanism including the driving shaft and configured to rotate the striker and the friction elements, wherein the friction elements are arranged on the driving shaft to be spaced apart from each other at a predetermined interval, and peripheral surfaces of bodies of the friction elements directly face the inner wall of the chamber with a predetermined distance therebetween.