Disclosed are techniques for wireless communication. In an aspect, a user equipment (UE) configured to operate in discontinuous reception (DRX) mode receives a configuration of a plurality of DRX groups, receives one or more positioning reference signal (PRS) configurations for the plurality of DRX groups, each of the one or more PRS configurations indicating one or more PRS resources for each of the plurality of DRX groups, receives one or more wakeup signals (WUS) for the plurality of DRX groups, the one or more WUS indicating whether or not the UE is expected to wake up for a next DRX cycle of each of the plurality of DRX groups, and measures/transmits the one or more PRS resources for each of the plurality of DRX groups during the next DRX cycle of each of the plurality of DRX groups based, at least in part, on the one or more WUS.