A computer-implemented system includes one or more processing devices configured to receive comorbidity information that includes a plurality of comorbidities or comorbidity-related conditions associated with a user, generate a selected set of the comorbidity information, determine, based on the selected set of the comorbidity information, respective probabilities of a plurality of different outcomes related to the comorbidity information, and generate, based on the respective probabilities and the selected set of the comorbidity information, a treatment plan comprising one or more exercises directed to changing the respective probabilities. A treatment apparatus is configured to implement the treatment plan while the treatment apparatus is being manipulated by the user.