The present invention relates to a method and a system for controlling a process of a process plant. Hie system is configured to control a process in the process plant by recommending control operations and perform the control operations. The system obtains the control operations and detects availability of control room operators using historical data related to actions performed by the control room operators, sensory parameters of the control room operators and a status associated with the process. The system provides queries related to the control operations, the plant parameters, status of the process to the control room operators upon detecting the availability. Hie queries are validated by the control room operators. The system thereafter autonomously controls tire control room based on the validated data.