- 专利标题： Trametinib prevents mesothelial-mesenchymal transition and ameliorates abdominal adhesion and pulmonary fibrosis formation
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申请号： US16607032申请日： 2018-04-20
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公开(公告)号： US11998550B2公开(公告)日： 2024-06-04
- 发明人: Joel Rosenbloom , Edward John Macarak
- 申请人： Thomas Jefferson University
- 申请人地址： US PA Philadephia
- 专利权人： THOMAS JEFFERSON UNIVERSITY
- 当前专利权人： THOMAS JEFFERSON UNIVERSITY
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Cozen O'Connor
- 国际申请： PCT/US2018/028516 2018.04.20
- 国际公布： WO2018/195392A 2018.10.25
- 进入国家日期： 2019-10-21
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K9/12 ; A61P11/00 ; A61P41/00
摘要：
A method of reducing the severity of abdominal adhesion due to surgical complications comprising: administering to said patient at least a first dose of trametinib between 0.01 mg to 2.0 mg, and after said surgical procedure, administering to said patient a further dose of trametinib between 0.01 mg to 2.0 mg, daily, for at least seven days post-surgery.
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