- 专利标题： Stable formulations comprising thiotepa
-
申请号： US17901284申请日： 2022-09-01
-
公开(公告)号： US11975013B2公开(公告)日： 2024-05-07
- 发明人: Sharon Cunningham , Orlaith Ryan , Johannes Jan Platteeuw
- 申请人： SHORLA PHARMA LTD.
- 申请人地址： IE County Tipperary
- 专利权人： SHORLA PHARMA LTD.
- 当前专利权人： SHORLA PHARMA LTD.
- 当前专利权人地址： IE Co. Tipperary
- 代理机构： Harness, Dickey & Pierce, P.L.C.
- 主分类号： A01N43/00
- IPC分类号： A01N43/00 ; A01N43/46 ; A61K9/08 ; A61K31/55 ; A61K31/675 ; A61K47/02 ; A61K47/10 ; A61K47/12 ; A61K47/18 ; A61K47/20 ; A61K47/22
摘要：
The present disclosure provides pharmaceutical compositions comprising thiotepa and one selected from PEG, such as PEG400 or PEG600, and DMSO, and optionally water or an aqueous saline solution and thiosulfate. The composition is free or substantially free of impurities. Also provided is a method for treating cancer in a subject, or myeloablation prior to bone marrow transplantation using the composition. A method for enhancing the stability of a thiotepa formulation is also contemplated.
公开/授权文献
- US20230017521A1 STABLE FORMULATIONS COMPRISING THIOTEPA 公开/授权日：2023-01-19
信息查询
IPC分类:
