![1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase](/docs/US/2024-05-07/US11975004B2/abs.jpg.600x600.jpg)
- 专利标题： 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
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申请号： US17228492申请日： 2021-04-12
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公开(公告)号： US11975004B2公开(公告)日： 2024-05-07
- 发明人: Tord Bertil Inghardt , Petra Johannesson , Ulrik Jurva , Erik Michaelsson , Eva-Lotte Lindstedt-Alstermark , Nicholas Tomkinson , Jeffrey Paul Stonehouse , Li-Ming Gan
- 申请人： AstraZeneca AB
- 申请人地址： SE Sodertalje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： SE Molndal
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/04
![1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase](/abs-image/US/2024/05/07/US11975004B2/abs.jpg.150x150.jpg)
摘要：
There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I),
and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.
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