This disclosure discloses signal configuration methods and apparatuses. In an implementation, a method comprises: generating at least two reference signals of a same type corresponding to at least two antenna ports indicated to a terminal device, wherein the at least two reference signals comprise a first reference signal and a second reference signal, wherein a first sequence of the first reference signal is obtained based on a first initialization factor determined based on an index of a first code division multiplexing (CDM) group, and wherein a second sequence of the second reference signal different from the first sequence is obtained based on a second initialization factor determined based on an index of a second CDM group; and transmitting the at least two reference signals.