A sterile spray pump, including a main piston (30), a spray head (40), and a secondary piston (50) fixed inside the spray head (40) and mounted in a vertically movable manner on the main piston (30). A first compression space (10) and a second compression space (20) are formed between the secondary piston (50) and the main piston (30); a main liquid suction cavity (301) communicating with the inner cavity of a container and an air supply port (302) communicating with the main liquid suction cavity (301) are provided in the main piston (30); the air supply port (302) communicates with the second compression space (20), a filter element (601) is fixedly provided in the air supply port (302); the secondary piston (50) includes a secondary liquid suction cavity (501) communicating with the main liquid suction cavity (301), a first exhaust member (502), and a second exhaust member (503).