The present disclosure provides a method, apparatus, and device for configuring a video special effect, and a storage medium, and relates to the technical field of special effect processing. The method includes: adding a first association node to a first special effect event combination in response to a first setting operation of a user; adding a second association node corresponding to the first association node to a second special effect event combination in response to a second setting operation of the user; and generating a configuration file of the video special effect according to the first special effect event combination and the second special effect event combination. The configuration file is configured to indicate that the video special effect is presented in a target video.