- 专利标题： Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
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申请号： US17244180申请日： 2021-04-29
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公开(公告)号： US11959073B2公开(公告)日： 2024-04-16
- 发明人: Andrew M. Scharenberg , Michael T. Certo , Kamila Sabina Gwiazda
- 申请人： SEATTLE CHILDREN'S HOSPITAL
- 申请人地址： US WA Seattle
- 专利权人： SEATTLE CHILDREN'S RESEARCH INSTITUTE
- 当前专利权人： SEATTLE CHILDREN'S RESEARCH INSTITUTE
- 当前专利权人地址： US WA Seattle
- 代理机构： Rothwell, Figg, Ernst & Manbeck, P.C.
- 分案原申请号： US14173705 2014.02.05
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; A61K9/00 ; A61K35/28 ; A61K38/45 ; A61K38/46 ; A61K38/52 ; C12N9/12 ; C12N9/16 ; C12N9/22 ; C12N9/90 ; C12N15/10 ; A61K35/12
摘要：
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
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