- 专利标题： Small molecule inhibitors of ALDH and uses thereof
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申请号： US16311533申请日： 2017-06-20
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公开(公告)号： US11944626B2公开(公告)日： 2024-04-02
- 发明人: Scott D. Larsen , Brandt C. Huddle , Kun Yang , Ronald Buckanovich , Thomas Hurley
- 申请人： The Regents of the University of Michigan , Indiana University Research and Technology Corporation
- 申请人地址： US MI Ann Arbor
- 专利权人： The Regents of the University of Michigan,Indiana University Research and Technology Corporation
- 当前专利权人： The Regents of the University of Michigan,Indiana University Research and Technology Corporation
- 当前专利权人地址： US MI Ann Arbor; US IN Indianapolis
- 代理机构： Casimir Jones, S.C.
- 代理商 Robert A. Goetz
- 国际申请： PCT/US2017/038334 2017.06.20
- 国际公布： WO2017/223086A 2017.12.28
- 进入国家日期： 2018-12-19
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K31/337 ; A61K31/4745 ; A61K31/522 ; A61K31/555 ; A61K31/7068 ; A61K39/395 ; A61K45/06 ; A61P31/00 ; A61P35/00 ; C07D487/04
摘要：
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.
公开/授权文献
- US20190255055A1 SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF 公开/授权日：2019-08-22
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