A machine frame for a machine tool is disclosed having two longitudinal members running in a first direction and two transverse members connecting the longitudinal members and running in a second direction running transversely to the first direction, wherein the longitudinal members and the transverse members define a machining space for the machine tool, at least two, preferably at least four, first floor fastening units for the predominant transmission of forces in the first direction into a foundation, wherein the first floor fastening units are fastened to end regions of the longitudinal members, and at least two second floor fastening units for the predominant transmission of forces in the second direction into the foundation, wherein the second floor fastening units are fastened to at least one of the longitudinal members in its central region, wherein the at least one of the longitudinal members has a cross-sectional geometry for the predominant force transfer in the second direction.