Invention Grant
- Patent Title: Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
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Application No.: US15567156Application Date: 2016-04-15
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Publication No.: US11896614B2Publication Date: 2024-02-13
- Inventor: David M. Barrett , Felipe Bedoya , Saba Ghassemi , Carl H. June , Bruce L. Levine , Jan J. Melenhorst , Michael C. Milone , Daniel J. Powell, Jr. , Nathan Amar Singh , Zoe Zheng
- Applicant: Novartis AG , The Trustees of the University of Pennsylvania
- Applicant Address: CH PA Basel
- Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee Address: CH Basel; US PA Philadelphia
- Agency: K&L Gates LLP
- International Application: PCT/US2016/027751 2016.04.15
- International Announcement: WO2016/168595A 2016.10.20
- Date entered country: 2017-10-17
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K14/47 ; C07K14/705 ; A61K38/50 ; A61K45/06 ; C07K16/28 ; C12N5/0783 ; C07K14/725 ; A61K39/00
Abstract:
The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
Public/Granted literature
- US20180133296A1 METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF CHIMERIC ANTIGEN RECEPTOR?EXPRESSING CELLS Public/Granted day:2018-05-17
Information query
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