Exemplary system, method, and computer-accessible medium can be provided for effectuating a video overlay during a medical procedure(s) performed on a patient(s) can include, for example, receiving a live video(s) of the medical procedure(s) performed on the patient(s), identifying, in real time, a target area(s), an area of danger(s) and/or at least partially obscured anatomical structures of significance on a patient's anatomy by applying a machine learning procedure to the live video(s), and providing the video overlay based on the identification of the target area(s) and the area of danger(s). The video overlay can be continuously modified, in real-time, using the machine learning procedure. The medical procedure(s) can be a gallbladder surgery. The machine learning procedure can include a neural network, which can be a convolutional neural network.