The present disclosure provides a method for processing projection data. The method may include obtaining a first image generated by performing a first scan to a subject by a first imaging device; determining first projection data based on the first image, the first projection data corresponding to a first area of the subject; obtaining second projection data by performing a second scan of the subject using a second imaging device, the second projection data corresponding to a second area of the subject, the first area at least partially overlapping with the second area in an overlapping area; determining registered first projection data by registering the first projection data to the second projection data with respect to the overlapping area; determining scatter component based on the registered first projection data and the second projection data, the scatter component including low-frequency scattered radiation signals.