A touch display panel and a manufacturing method therefor, and a touch display device. The touch display panel comprises a touch display region and a peripheral region. The touch display region comprises a through hole, a through hole detection region surrounding the through hole, and a transition connection region located between the through hole detection region and the peripheral region. The through hole detection region comprises an annular crack detection line and an annular isolation line. The transition connection region comprises a transition crack detection line and a transition isolation line. The peripheral region comprises an edge crack detection line and an edge isolation line.