Provided are a display driving method and device, liquid crystal controller, display system and projection device. The method comprises: acquiring driving configuration information of the liquid crystal module, the driving configuration information is used for indicating the number of configured LCD drivers; receiving a color image frame, and decomposing the color image frame into 3 monochrome frame images; performing segmentation processing on each monochrome frame image to obtain monochrome frame segmentation image data corresponding to each display area of the liquid crystal module; packaging the monochrome frame segmentation image data corresponding to each display area, and sending data to the LCD driver corresponding to each display area; after the LCD driver receives the monochrome frame segmentation image data, writing, by the LCD driver the received monochrome frame segmentation image data into the liquid crystal module to drive the display area corresponding to the liquid crystal module to display.