A system configured to implement Comprehensive Contention-Based Thread Allocation and Placement, may generate a description of a workload from multiple profiling runs and may combine this workload description with a description of the machine's hardware to model the workload's performance over alternative thread placements. For instance, the system may generate a machine description based on executing stress applications and machine performance counters monitoring various performance indicators during execution of a synthetic workload. Such a system may also generate a workload description based on profiling sessions and the performance counters. Additionally, behavior of a workload with a proposed thread placement may be modeled based on the machine description and workload description and a prediction of the workload's resource demands and/or performance may be generated.