- 专利标题： IL-17 receptor A antigen binding proteins
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申请号： US16985868申请日： 2020-08-05
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公开(公告)号： US11858999B2公开(公告)日： 2024-01-02
- 发明人: Joel E. Tocker , Jacques J. Peschon , David Fitzpatrick , James F. Smothers , Christopher Mehlin , Ai Ching Lim
- 申请人： AMGEN K-A, INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN K-A, INC.
- 当前专利权人： AMGEN K-A, INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： Casimir Jones SC
- 代理商 Lisa Mueller
- 分案原申请号： US12443962
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; A61K45/06 ; A61K39/00
摘要：
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.
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