A method and apparatus that cancels or reduces DC offset in a fully-differential optical receiver. The method includes receiving differential optical signals, converting, with photodetectors, the differential optical signals to differential current signals representative of the differential optical signals, converting, using a transimpedance amplifier, the differential current signals to differential intermediate voltage signals, amplifying, using a main amplifier, the differential intermediate voltage signals to generate differential output voltage signals, and cancelling a DC component of the differential output voltage signals using a fully differential DC cancellation circuit. Output offset may also be cancelled or reduced using digital control.