![Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors](/docs/US/2023-12-05/US11834453B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
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申请号： US17362580申请日： 2021-06-29
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公开(公告)号： US11834453B2公开(公告)日： 2023-12-05
- 发明人: Mark Laurence Boys , Bryan Daniel Ellis , John Joseph Gaudino , Erik James Hicken , Ellen Ruth Laird , Nicholas Charles Lazzara , Bradley Jon Newhouse , Spencer Phillip Pajk
- 申请人： Array BioPharma Inc.
- 申请人地址： US CO Boulder
- 专利权人： Array BioPharma Inc.
- 当前专利权人： Array BioPharma Inc.
- 当前专利权人地址： US NY New York
- 代理商 Corey M. Williams
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/04 ; A61K45/06 ; C07D519/00
![Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors](/abs-image/US/2023/12/05/US11834453B2/abs.jpg.150x150.jpg)
摘要：
This invention relates to compounds of Formula (I):
and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.
and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.
公开/授权文献
- US20230023851A1 HER2 MUTATION INHIBITORS 公开/授权日：2023-01-26
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