- 专利标题： Human antibodies to human delta like ligand 4
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申请号： US16892336申请日： 2020-06-04
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公开(公告)号： US11820815B2公开(公告)日： 2023-11-21
- 发明人: Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 代理机构： McCarter & English, LLP
- 代理商 Marcie B. Clarke; Deborah L. Nagle
- 分案原申请号： US12002245 2007.12.14
- 主分类号： C07K16/22
- IPC分类号： C07K16/22 ; C07K16/18 ; A61K39/00
摘要：
The present invention provides methods of treating, ameliorating, or inhibiting tumor growth, cancer, or pathological angiogenesis by administering to a subject in need thereof a human antibody or fragment thereof that specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The anti-hDll4 antibody or fragment thereof of the present invention have a high affinity with the KD of 500 pM or less, as measured by surface plasmon resonance.
公开/授权文献
- US20220025030A1 HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4 公开/授权日：2022-01-27
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