A computer implemented method is disclosed for providing adaptive control of a gas mixture for delivery to a patient via a separate external gas blender system. The computer implemented method includes receiving first SpO2 data from a regional oximeter via a regional oximeter interface; determining first PaO2 data using a first lookup table derived from a first sigmoid shaped oxyhemoglobin dissociation curve; determining a first gas mixture value using the first PaO2 data; and transmitting first adaptive feedback control data including the first gas mixture value to the separate external gas blender system via a gas blender interface.