A method for establishing a denture dentition model includes: obtaining face information and teeth alignment information of a use, to establish a three-dimensional mouth-opening face model and an original teeth model, and superimposing the original teeth model to the three-dimensional mouth-opening face model; establishing a reference line corresponding to each of the teeth of the original teeth model; generating a plurality of grids on the three-dimensional mouth-opening face model according to the reference lines, and adjusting each of the grids to correspond to the edge of each tooth, to obtain an actual size of each of the teeth; providing an upper edge curve and a lower edge curve on the three-dimensional mouth-opening face model as a smile curve; aligning each grid with the smile curve, and placing a denture model in each grid; and adjusting a denture contour of each denture model, to generate the denture dentition model.