Filter media including a filtration layer comprising fibers (e.g., synthetic fibers) comprising a flame retardant and related components, systems, and methods associated herewith are provided. In some embodiments, a filtration layer may include a nonwoven web (e.g., wet-laid nonwoven web) comprising fibers including a certain flame retardant that has a relatively low concentration of or is substantially free of certain undesirable and/or toxic components (e.g., halogens). In certain embodiments, the nonwoven web may also comprise a blend of fibers. For instance, in some embodiments, the nonwoven web may also comprise a blend of coarse and fine diameter synthetic fibers that impart beneficial performance properties to the filtration layer. In some embodiments, the filtration layer may be designed to have a desirable flame retardancy (e.g., F1 rating, K1 rating) and performance properties without compromising certain mechanical properties (e.g., pleatability of the media) and/or environmental attributes (e.g., relatively low toxicity). Filter media described herein may be particularly well-suited for applications that involve filtering air, though the media may also be used in other applications.