Provided is an apparatus for manufacturing a surgical guide that guides a cutting line formed to surround a tumor of an organ, the apparatus including: an organ modeling unit configured to model a 3-dimensional (3D) image of the organ, based on an image of a patient captured by an external imaging apparatus; a cutting line determining unit configured to determine, in the 3D image of the organ, the cutting line to correspond to a location of the tumor and an entry angle of a surgical instrument to the cutting line; and a guide manufacturing unit configured to manufacture a surgical guide that guides the surgical instrument to the cutting line in a slanting manner corresponding to the entry angle, based on the 3D image of the organ.