Embodiments for intelligent collaborative generation or enhancement of useful medical actions to a user by a processor. One or more useful medical actions may be recommended, with evidence in support thereof, for positively impacting a health state of a user according to data relating to similar users. One or more of the recommended user medical actions may be matched to one or more selected portions of clinical practice guidelines (CPGs). The one or more of the recommended user medical actions may be added as an additional CPG or as an enhancement to one or more of the matching portions of the recommended user medical actions.