A radio frequency (RF) unit, a digital unit, and methods of transmitting and receiving data in a wireless communication system are provided. The digital unit may include: a transceiver configured to receive compressed data from an RF unit, a processor configured to divide a frequency domain and a time domain into a plurality of blocks, set a compression parameter to be applied to each of the plurality of blocks, and expand the received data in units of the blocks based on the set compression parameter, and a memory storing the compression parameter.