发明授权
- 专利标题： Tri-specific binding molecules that specifically bind to multiple cancer antigens
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申请号： US16805105申请日： 2020-02-28
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公开(公告)号： US11697684B2公开(公告)日： 2023-07-11
- 发明人: Ezio Bonvini , Paul A. Moore , Jonathan C. Li , Leslie S. Johnson , Kalpana Shah
- 申请人： MACROGENICS, INC.
- 申请人地址： US MD Rockville
- 专利权人： MACROGENICS, INC.
- 当前专利权人： MACROGENICS, INC.
- 当前专利权人地址： US MD Rockville
- 代理机构： Medler Ferro Woodhouse & Mills
- 分案原申请号： US15313765
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/30
摘要：
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.
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