An information handling system includes an antenna controller that may receive, from a platform sensor, platform sensor information as to a physical configuration usage mode, and receive, from a proximity sensor, information as to a part of a body of a user to an antenna. The antenna controller may also obtain a radio transmit power level value corresponding to the platform sensor information and to the proximity sensing information, send the radio transmit power level value to a radio via a serial interface, and reconfigure the antenna in response to the platform sensor information and the proximity sensing information. A radio may adjust a radio transmit power level to an adjusted radio transmit power level based on the radio transmit power level value.