A protective guard is provided for sealing an interface. The protective guard includes a body having a fluid impervious material and proximal and distal segments that may comprise a superabsorbent or a non-superabsorbent material. The proximal and distal segments are positioned on first and second sides, respectively, of the interface. The protective guard extends about the interface to create a fluid barrier. In some embodiments, the non-superabsorbent material may be an elastic material, such as an elastic band, and in particular embodiments, the non-superabsorbent material may be nitrile. In further embodiments, the non-superabsorbent material may be an expandable material that expands upon contact or interaction with a fluid.